1020107-14-5Relevant academic research and scientific papers
Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors
Goeminne,McNaughton,Bal,Surpateanu,Van Der Veken,De Prol,Versees,Steyaert,Haemers,Augustyns
, p. 315 - 326 (2008/09/18)
Nucleoside hydrolase (NH) is a key enzyme in the purine salvage pathway. The purine specificity of the IAG-NH from Trypanosoma vivax is at least in part due to cation-π-stacking interactions. Guanidinium ions can be involved in cation-π-stacking interactions, therefore a series of guanidino-alkyl-ribitol derivatives were synthesized in order to examine the binding affinity of these compounds towards the target enzyme. The compounds show moderate to good inhibiting activity towards the IAG-NH from T. vivax.
