102014-58-4

Upstream product

• 68144-41-2 1-Azido-1-methylcyclopentan 
• 96-37-7 methyl-cyclopentane 
• 801282-64-4 1-methyl-1-cyclopentylformamide 
• 6196-85-6 1-chloro-1-methylcyclopentane 
• 4648-54-8 trimethylsilylazide 
• 1462-03-9 1-methylcyclopentanol 

Downstream Products

• 801282-70-2 C₂₀H₃₀N₂O₃ 
• 1037254-63-9 tert-butyl [(1S)-1-(4-{(1S)-1-hydroxy-2-[(1-methylcyclopentyl)amino]ethyl}phenyl)ethyl]carbamate 
• 693-89-0 1-methylcyclopent-1-ene 
• 1462-03-9 1-methylcyclopentanol 

Relevant academic research and scientific papers

One-Pot Synthesis of Primary and Secondary Aliphatic Amines via Mild and Selective sp3 C?H Imination

The direct replacement of sp3 C?H bonds with simple amine units (?NH2) remains synthetically challenging, although primary aliphatic amines are ubiquitous in medicinal chemistry and natural product synthesis. We report a mild and selective protocol for preparing primary and secondary aliphatic amines in a single pot, based on intermolecular sp3 C?H imination. The first C?H imination of diverse alkanes, this method shows useful site-selectivity within substrates bearing multiple sp3 C?H bonds. Furthermore, this reaction tolerates polar functional groups relevant for complex molecule synthesis, highlighted in the synthesis of amine pharmaceuticals and amination of natural products. We characterize a unique C?H imination mechanism based on radical rebound to an iminyl radical, supported by kinetic isotope effects, stereoablation, resubmission, and computational modeling. This work constitutes a selective method for complex amine synthesis and a new mechanistic platform for C?H amination.

DICYANOPYRROLIDINES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS

The invention provides compounds of formula (I), the prodrugs and stereoisomers thereof, and the pharmaceutically acceptable salts of the compounds, prodrugs, and stereoisomers, wherein wherein R is as defined herein; pharmaceutical compositions thereof;

HEPATITIS C INHIBITOR COMPOUNDS

Compounds of formula (I): wherein B, X, R3, L0, L1, L2, R2, R1 and RC are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection.

A Simple, One-Pot Transformation of t-Alkyl Chlorides Into (t-Alkyl)amines

t-Alkyl chlorides are readily azidated using trimethylsilyl azide in the presence of tin tetrachloride.Tertiary azides can be transformed without isolation into the corresponding (t-alkyl)amine hydrochlorides in a one-pot procedure employing the Staudinger reaction.