1020153-98-3Relevant academic research and scientific papers
Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists
Biggadike, Keith,Caivano, Matilde,Clackers, Margaret,Coe, Diane M.,Hardy, George W.,Humphreys, Davina,Jones, Haydn T.,House, David,Miles-Williams, Annette,Skone, Philip A.,Uings, Iain,Weller, Vicki,McLay, Iain M.,Macdonald, Simon J.F.
scheme or table, p. 4846 - 4850 (2010/05/18)
Starting from a non-steroidal glucocorticoid agonist aryl pyrazole derivative, the NFκB agonist activity was optimised in an iterative process from pIC50 7.5 (for 7), to pIC50 10.1 (for 38E1). An explanation for the SAR observed base
NOVEL COMPOUNDS
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Page/Page column 64, (2008/06/13)
The present invention provides glucocorticoid receptor agonists of formula (I), a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the
