1020168-40-4Relevant academic research and scientific papers
Microwave-assisted, highly enantioselective addition of diethylzinc to aromatic aldehydes catalyzed by chiral aminonaphthols
Szatmari, Istvan,Sillanpaeae, Reijo,Fueloep, Ferenc
, p. 612 - 617 (2008)
New optically active aminonaphthols were obtained by condensation of 2-naphthol, benzaldehyde and (R)-(+)-1-(1-naphthyl)ethylamine or (R)-(+)-1-(2-naphthyl)ethylamine. Their N-methylated derivatives were also synthesized. The new aminonaphthols 2, 4, 5 and 7 were found to catalyze the enantioselective ethylation of aryl aldehydes to 1-aryl-1-propanols (up to 92% ee). The reactions were accelerated greatly by microwave irradiation.
