102022-69-5Relevant academic research and scientific papers
A facile scheme for phthalimide ? phthalimidine conversion
Luzzio, Frederick A.,Piatt Zacherl, DeAnna,Figg, William D.
, p. 2087 - 2090 (1999)
Desulfurization of phenylthiolactams using an ultrasound-promoted Raney nickel protocol yields the corresponding N-substituted phthalimidines. Benzylic oxidation of the N-substituted phthalimidines by treatment with 2,2'-bipyridinium chlorochromate/m-chloroperbenzoic acid (BPCC/MCPBA) affords the original phthalimides. The reduction-desulfurization is applied to the preparation of a deoxythalidomide derivative which is a TNF-α inhibitor.
