1020264-96-3Relevant academic research and scientific papers
N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents
Matesic, Lidia,Locke, Julie M.,Bremner, John B.,Pyne, Stephen G.,Skropeta, Danielle,Ranson, Marie,Vine, Kara L.
, p. 3118 - 3124 (2008/09/20)
A range of N-phenethyl, N-phenacyl, and N-(1- and 2-naphthylmethyl) derivatives of 5,7-dibromoisatin 2 were prepared by N-alkylation reactions. Their activity against human monocyte-like histiocytic lymphoma (U937), leukemia (Jurkat), and breast carcinoma
SELECTIVELY DELIVERABLE ISATIN-BASED CYTOTOXIC AGENTS
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Page/Page column 55, (2008/12/06)
The invention relates to compounds comprising a cytotoxic isatin derivative conjugated to a cell targeting moiety via a spacer group. These conjugates allow the cytotoxic isatin derivaties to be targeted to particular cell and tissue types. The invention
