1020267-39-3Relevant articles and documents
Total synthesis of the marine metabolite (-)-clavosolide D
Seden, Peter T.,Charmant, Jonathan P. H.,Willis, Christine L.
, p. 1637 - 1640 (2008)
The first total synthesis of the marine natural product (-)-clavosolide D is described confirming the structure of the unsymmetrical 16- membered diolide glycosylated by permethylated D-xylose moieties. Following efficient assembly of the two tetrahydropyrans using stereoselective Prins cyclizations, the side chains were introduced via an allylation/isomerization/anti cyclopropanation sequence; the final macrolactonization step was achieved under Yamaguchi conditions.2008 American Chemical Society.