1020280-73-2Relevant academic research and scientific papers
RETINOID PRODRUG COMPOUND
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Page/Page column 10, (2010/08/18)
A compound represented by the following general formula (I) : [R1 to R5 represent hydrogen atom, an alkyl group, or a trialkylsilyl group, X represents -NH-CO-, -CO-NH-, -N(COR6)-CO-, -CO-N(COR7)- (R6 and R7 represent a lower alkoxy group, or a carboxy-substituted phenyl group) etc.; and Z represents -Y-CH(R12)-COOH, -CHO, -CH-CH-COOH, or -COOR13 (Y represents a single bond, -CH2-, -CH(OH)-, -CO-, -CO-NH-, or -CO-NH-CH2-CO-NH-, R12 represents hydrogen atom or a lower alkyl group, and R13 represents hydrogen atom, -CH(R14)-COOH (R14 represents hydrogen atom, a lower alkyl group, or hydroxy group), -[CH2CH2-O]n-CH2-CH2-OH, CH2-O-[CH2CH2O]m-CH2-OH, or -[CH(CH3)-CO-O]p-CH(CH3)-COOH (m, n and p represent an integer of 1 to 100))], a salt thereof or an ester thereof, which has a property of being converted into a retinoid after absorption in vivo.
RETINOID PRODRUG COMPOUND
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Page/Page column 8, (2010/12/29)
A compound represented by the following general formula (I): [R1 to R5 represent hydrogen atom, an alkyl group, or a trialkylsilyl group, X represents —NH—CO—, —CO—NH—, —N(COR6)—CO—, —CO—N(COR7)— (R6 and R7 represent a lower alkoxy group, or a carboxy-substituted phenyl group) etc.; and Z represents —Y—CH(R12)—COOH, —CHO, —CH═CH—COOH, or —COOR13 (Y represents a single bond, —CH2—, —CH(OH)—, —CO—, —CO—NH—, or —CO—NH—CH2—CO—NH—, R12 represents hydrogen atom or a lower alkyl group, and R13 represents hydrogen atom, —CH(R14)—COOH(R14 represents hydrogen atom, a lower alkyl group, or hydroxy group), —[CH2CH2—O]n—CH2—CH2—OH, —CH2—O—[CH2CH2—O]m—CH2—OH, or —[CH(CH3)—CO—O]p—CH(CH3)—COOH (m, n and p represent an integer of 1 to 100))], a salt thereof or an ester thereof, which has a property of being converted into a retinoid after absorption in vivo.
