1020534-65-9Relevant academic research and scientific papers
Enantioselective synthesis of β-blockers via hydrolytic kinetic resolution of terminal oxiranes by using bimetallic chiral {{2,2′- [cyclohexane-1,2-diylbis(nitrilomethylidyne)]bis[phenolato]}(2-)}cobalt ([Co(salen)])-type complexes
Kawthekar, Rahul B.,Kim, Geon-Joong
, p. 317 - 332 (2008)
The synthesis of chirally pure β-blockers was successfully achieved via hydrolytic kinetic resolution of butyl (±)-4-(oxiran-2-ylmethoxy) benzeneacetate ((±)-1) and (±)-4-(oxiran-2-ylmethoxy) benzeneacetonitrile ((±)-2) in the presence of bimetallic chiral [Co(salen)]-type complexes. The newly synthesized bimetallic chiral [Co(salen)]-type complexes exhibited excellent enantioselectivities of up to >98% ee in good yields (Tables 1-3).
