1020536-62-2Relevant academic research and scientific papers
Design, synthesis and biological evaluation of biphenylurea derivatives as VEGFR-2 kinase inhibitors (II)
Gao, Guo-Rui,Li, Meng-Yuan,Lv, Yong-Cong,Cao, Su-Fen,Tong, Lin-Jiang,Wei, Li-Xin,Ding, Jian,Xie, Hua,Duan, Wen-Hu
, p. 200 - 204 (2016)
Inhibition of VEGFR-2 signaling pathway is one of the most promising approaches for the treatment of cancer. In this paper, we reported the design, synthesis, and biological evaluation of a series of biphenylurea derivatives as VEGFR-2 inhibitors. Among t
KINASE INHIBITORS AND USES THEREOF
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Page/Page column 174; 175, (2008/12/05)
The present invention relates to compounds of the general formula (A) and pharmaceutical compositions thereof that inhibit protein tyrosine activity. In particular the invention relates to said compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signalling, for example, the inhibition of VEGF receptor signalling and HGF receptor signalling. Said compounds and compositions are useful for the treatment of cell proliferative diseases and conditions.
