1020539-05-2Relevant academic research and scientific papers
Enantioselective synthesis of the central ring system of lomaiviticin A in the form of an unusually stable cyclic hydrate
Krygowski, Evan S.,Murphy-Benenato, Kerry,Shair, Matthew D.
, p. 1680 - 1684 (2008)
(Chemical Equation Presented) A model system representing a protected form of the four central rings of the antitumor compound lomaiviticin A has been synthesized (outlined in red in the picture). The approach features an intramolecular furan Diels-Alder reaction, a stereoselective oxidative enolate coupling to dimerize the halves, and a base-initiated cascade reaction. The 1,4-diketone of the central ring system exists as a stable cyclic hydrate.
