1020701-52-3Relevant academic research and scientific papers
Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction
Shen, Zuyuan,Zhang, Shilei,Geng, Huihui,Wang, Jiarui,Zhang, Xinyu,Zhou, Anqi,Yao, Cheng,Chen, Xiaobei,Wang, Wei
, p. 448 - 452 (2019/01/14)
A conceptually novel sulfoxonium metathesis reaction between TMSOI and cost-effective DMSO-d6 is developed for the efficient generation of a new trideuteromethylation reagent TDMSOI. The new reagent TDMSOI is produced highly efficiently by simply heating a mixture of TMSOI and DMSO-d6 and directly used for subsequent trideuteromethylation in a "one-pot" operation. The preparative power of the new versatile reagent and the "one-pot" protocol is demonstrated by its use to install the ?CD3 moiety into broad functionalities including phenols, thiophenols, acidic amines, and enolizable methylene units in high yield and at a useful level of deuteration (>87% D).
INDOLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Page/Page column 3, (2010/08/18)
Compounds of formula (I): wherein: R1 represents an alkyl, cycloalkyl or cycloalkylalkyl group,R2 and R3, together with the nitrogen atom carrying them, form a heterocycle having from 5 to 8 ring members,and n represents from 2 to 6. Medicinal products containing the same which are useful in treating disorders of the to melatoninergic system.
