1020746-00-2Relevant academic research and scientific papers
Highly regioselective synthesis of trisubstituted allenes via lithiation of 1-Aryl-3-alkylpropadiene, subsequent transmetalation, and Pd-catalyzed negishi coupling reaction
Zhao, Jinbo,Liu, Yu,Shengming, Ma.
supporting information; experimental part, p. 1521 - 1523 (2009/04/12)
A novel methodology for the synthesis of trisubstituted allenes is reported. Lithiation of 1-aryl-3-alkylpropadienes and subsequent transmetalation with zinc bromide followed by Pd-catalyzed Negishi coupling reactions with halides afforded the corresponding trisubstituted allenes in a highly regioselective fashion with moderate to excellent yields. A plausible regioselective lithiation mechanism was proposed on the basis of deuterium labeling experiments.
