1020850-42-3Relevant articles and documents
The telescoped intramolecular Michael/olefination (TIMO) approach to α-alkylidene-γ-butyrolactones: Synthesis of (+)-paeonilactone B
Edwards, Michael G.,Kenworthy, Martin N.,Kitson, Russell R. A.,Scott, Mark S.,Taylor, Richard J. K.
, p. 1935 - 1937 (2008/12/22)
(Chemical Equation Presented) Scoping out TIMO: A telescoped intramolecular Michael addition/proton transfer/ Horner-Wadsworth-Emmons olefination sequence was developed to provide rapid access to α-alkylidene-γ- butyrolactones (see scheme). The method was applied to prepare a range of tetrahydrobenzofuran-2,5-diones and related systems, and it was utilized in a short synthesis of enantiomerically pure (+)-paeonilactone B.
