1020935-97-0Relevant articles and documents
Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase
Martin, Joseph A.,Lambert, Robert W.,Merrett, John H.,Parkes, Kevin E.B.,Thomas, Gareth J.,Baker, Stewart J.,Bushnell, David J.,Cansfield, Julie E.,Dunsdon, Stephen J.,Freeman, Andrew C.,Hopkins, Richard A.,Johns, Ian R.,Keech, Elizabeth,Simmonite, Heather,Walmsley, Andrea,Wong Kai-In, Philippe,Holland, Mark
, p. 1655 - 1658 (2001)
A series of carboxamide derivatives of 5′-amino-2′,5′-dideoxy-5-ethyluridine has been prepared as inhibitors of HSV-TK (herpes simplex virus thymidine kinase). The most potent compounds were derived from xanthene, thioxanthene and dihydroanthracene carboxylic acids. The lead compounds show subnanomolar IC50 values against HSV TKs.
