102096-41-3Relevant academic research and scientific papers
Possible Antimalarial Agents: Syntheses of 6-Methoxy-8-substituted-aminoquinolines
Bhat, Balkrishen,Bhaduri, A. P.
, p. 419 - 423 (2007/10/02)
Syntheses of 8-(2-amino-2-alkyl- or aryl-ethylamino)-6-methoxyquinolines (10-12), 8--6-methoxyquinolines (19-20), 8-(2-hydroxy-3-substituted-phenoxypropylamino)-6-methoxyquinolines (21-27) and 8--6-methoxyquinoline (30) are described.All the compounds have been evaluated for their blood and tissue schizontocidal activities and among these 17 shows tissue schizontocidal activity at 40 and 20 mg/kg i.p. doses against Plasmodium berghei NK-65 strain in Mastomysnatalensis.Compounds 21-23 have also been evaluated for their antarrhythmic activity and among these 21 shows moderate activity.
