1021000-12-3

Basic information

• Product Name: 4-(3-fluorophenoxy)benzoic acid
• Synonyms: 4-(3-fluorophenoxy)benzoic acid
• CAS NO: 1021000-12-3
• Molecular Formula: C₁₃H₉FO₃
• Molecular Weight: 232.2071632
• Mol File: 1021000-12-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(3-fluorophenoxy)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-fluorophenoxy)benzoic acid(1021000-12-3)
• EPA Substance Registry System: 4-(3-fluorophenoxy)benzoic acid(1021000-12-3)

Safety Data

• Hazardous Substances Data: 1021000-12-3(Hazardous Substances Data)

Upstream product

• 372-20-3 3-fluorophenol 
• 459-57-4 4-fluorobenzaldehyde 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 939758-29-9 4-(3-fluorophenoxy)benzaldehyde 
• 877149-18-3 4-((3'-fluoro)phenoxy)benzonitrile 
• 1194-02-1 4-fluorobenzonitrile 
• 1044060-37-8 methyl 4-(3-fluorophenoxy)benzoate 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 768-35-4 3-fluorophenylboronic acid 

Downstream Products

• 1382992-74-6 N-(2-(5-chloro-1H-indol-3-yl)ethyl)-4-(3-fluorophenoxy)benzamide 
• 1442121-12-1 2-({1-[4-(3-fluorophenoxy)benzoyl]piperidin-4-yl}methyl)-N-(2-methoxyethyl)-4-methyl-2H-indazole-5-carboxamide 
• 1442120-58-2 2-({1-[4-(3-fluorophenoxy)benzoyl]piperidin-4-yl}methyl)-4-methyl-N-(2,2,2-trifluoroethyl)-2H-indazole-5-carboxamide 
• 1436378-58-3 N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl}-2-methylpropyl-4-(3-fluorophenoxy)benzamide 

Relevant articles and documents

Synthesis and structure–activity relationship of N-(piperidin-4-yl)benzamide derivatives as activators of hypoxia-inducible factor 1 pathways

Guided by bioisosterism and pharmacokinetic parameters, we designed and synthesized a series of novel benzamide derivatives. Preliminary in vitro studies indicated that compounds 10b and 10j show significant inhibitory bioactivity in HepG2 cells (IC50 values of 0.12 and 0.13?μM, respectively). Compounds 10b and 10j induced the expression of HIF-1α protein and downstream target gene p21, and upregulated the expression of cleaved caspase-3 to promote tumor cells apoptosis.

1-SUBSTITUTED 4-ARYLPIPERAZINE AS KAPPA OPIOID RECEPTOR ANTAGONISTS

Provided are compounds represented by the formula: where R, Y3, R1,R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.

INHIBITORS OF BRUTON'S TYROSINE KINASE

Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.