1021167-95-2Relevant articles and documents
Discovery of {4-[4,9-bis(ethyloxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-2-fluorophenyl}acetic acid (GSK726701A), a novel EP4 receptor partial agonist for the treatment of pain
Healy, Mark P.,Allan, Amanda C.,Bailey, Kristin,Billinton, Andy,Chessell, Iain P.,Clayton, Nicholas M.,Giblin, Gerard M.P.,Kay, Melanie A.,Khaznadar, Tarik,Michel, Anton D.,Naylor, Alan,Price, Helen,Spalding, David J.,Stevens, David A.,Swarbrick, Martin E.,Wilson, Alexander W.
, p. 1892 - 1896 (2018/05/17)
A novel series of EP4 agonists and antagonists have been identified, and then used to validate their potential in the treatment of inflammatory pain. This paper describes these novel ligands and their activity within a number of pre-clinical mo
