1021167-95-2Relevant academic research and scientific papers
Discovery of {4-[4,9-bis(ethyloxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-2-fluorophenyl}acetic acid (GSK726701A), a novel EP4 receptor partial agonist for the treatment of pain
Healy, Mark P.,Allan, Amanda C.,Bailey, Kristin,Billinton, Andy,Chessell, Iain P.,Clayton, Nicholas M.,Giblin, Gerard M.P.,Kay, Melanie A.,Khaznadar, Tarik,Michel, Anton D.,Naylor, Alan,Price, Helen,Spalding, David J.,Stevens, David A.,Swarbrick, Martin E.,Wilson, Alexander W.
, p. 1892 - 1896 (2018/05/17)
A novel series of EP4 agonists and antagonists have been identified, and then used to validate their potential in the treatment of inflammatory pain. This paper describes these novel ligands and their activity within a number of pre-clinical mo
ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS
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Page/Page column 26, (2008/12/05)
The present invention relates to indole derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine.
