102124-09-4Relevant articles and documents
Asymmetric Michael addition organocatalyzed by α,β-dipeptides under solvent-free reaction conditions
Avila-Ortiz, C. Gabriela,Lenin, Diaz-Corona,Erika, Jiménez-González,Juaristi, Eusebio
, (2017/09/01)
The application of six novel α,β-dipeptides as chiral organocatalysts in the asymmetric Michael addition reaction between enolizable aldehydes and N-arylmaleimides or nitroolefins is described. With N-arylmaleimides as substrates, the best results were achieved with dipeptide 2 as a catalyst in the presence of aq. NaOH. Whereas dipeptides 4 and 6 in conjunction with 4-dimethylaminopyridine (DMAP) and thiourea as a hydrogen bond donor proved to be highly efficient organocatalytic systems in the enantioselective reaction between isobutyraldehyde and various nitroolefins.