102129-66-8 Usage
Description
ALA-ALA-PHE-CHLOROMETHYLKETONE TFA is a chemical compound composed of the amino acids alanine-alanine-phenylalanine, with a chloromethylketone functional group and a trifluoroacetic acid (TFA) counterion. It is known for its ability to irreversibly bind to the active site serine of proteases, effectively inhibiting their activity.
Uses
Used in Biochemical and Biological Research:
ALA-ALA-PHE-CHLOROMETHYLKETONE TFA is used as a protease inhibitor for enzymes with a serine residue at the active site. Its chloromethylketone moiety forms a covalent bond with the active site serine, thereby inhibiting the protease activity. This property makes it a valuable tool in studying the function and regulation of proteolytic enzymes in various biological processes.
Used in Pharmaceutical Development:
Due to its ability to inhibit protease activity, ALA-ALA-PHE-CHLOROMETHYLKETONE TFA can be utilized in the development of drugs targeting proteases involved in diseases such as cancer, inflammation, and neurodegenerative disorders. By inhibiting the activity of these proteases, the compound may help in controlling the progression of these diseases and improving treatment outcomes.
Used in Drug Delivery Systems:
To enhance the efficacy and bioavailability of ALA-ALA-PHE-CHLOROMETHYLKETONE TFA, various drug delivery systems can be employed. These systems, such as nanoparticles or liposomes, can improve the compound's solubility, stability, and targeted delivery to specific cells or tissues, thereby increasing its therapeutic potential.
Used in Diagnostic Applications:
The ability of ALA-ALA-PHE-CHLOROMETHYLKETONE TFA to bind irreversibly to proteases can also be utilized in diagnostic assays to detect the presence or activity of specific proteases in biological samples. This can aid in the diagnosis and monitoring of diseases associated with abnormal protease activity.
Check Digit Verification of cas no
The CAS Registry Mumber 102129-66-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,1,2 and 9 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 102129-66:
(8*1)+(7*0)+(6*2)+(5*1)+(4*2)+(3*9)+(2*6)+(1*6)=78
78 % 10 = 8
So 102129-66-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H22ClN3O3/c1-10(18)15(22)20-16(23)11(2)19-13(14(21)9-17)8-12-6-4-3-5-7-12/h3-7,10-11,13,19H,8-9,18H2,1-2H3,(H,20,22,23)/t10-,11-,13-/m0/s1
