1021393-18-9

Upstream product

• 1021393-17-8 3-chloro-6-hydrazinyl-N-phenylpicolinamide 
• 123-54-6 acetylacetone 
• 1021043-37-7 3,6-dichloro-N-phenylpicolinamide 
• 16866-53-8 3,6-dichloropyridine-2-carboxylic acid chloride 

Relevant academic research and scientific papers

Picolinamide rhodium complex as well as synthesis method and application thereof

The invention discloses a series of picolinamide rhodium complexes as well as a synthesis method and application thereof. The picolinamide rhodium complex is prepared by heating and reacting a picolinamide derivative containing a pyrazole substitution unit and rhodium trichloride in a mixed solvent composed of chloroform and methanol or acetonitrile and methanol. The synthesis route is simple, raw materials are easy to obtain, and the yield is high. Test results of the applicant show that the complexes have a remarkable anti-proliferation effect on various tumor cell strains, the activity of most complexes is remarkably higher than that of cis-platinum, and the complexes are expected to be developed into anti-tumor drugs.

Synthesis, characterization and luminescence properties of Eu(III) and Tb(III) complexes with novel pyrazole derivatives and 1,10-phenanthroline

Two novel pyrazole-derived ligands, 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinic acid (CDPA) and 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)-N-phenylpicolinamide (CDPP) were prepared by 3,6-dichloropicolinic acid (DCPA). Their complexes with terbium(III) and europium(III) were synthesized. The complexes were characterized by elemental analysis, infrared spectra, 1H NMR and TG-DTG. Furthermore, the above complexes using 1,10-phenanthroline as a secondary ligand were also synthesized and characterized. The luminescence properties of these complexes in solid state were investigated. The results suggested that Tb(III) complexes exhibit more efficient luminescence than Eu(III) complexes and the fluorescence of the complexes with 1,10-phenanthroline as a secondary ligand was prominently stronger than that of complexes without this ligand., and the three ligand (DCPA), (CDPP) and (CDPA) are excellent sensitizers to Eu(III) and Tb(III) ion.