1021394-85-3Relevant academic research and scientific papers
Enamine catalysis with low catalyst loadings - High efficiency via kinetic studies
Wiesner, Markus,Upert, Gregory,Angelici, Gaetano,Wennemers, Helma
, p. 6 - 7 (2010)
(Chemical Equation Presented) Kinetic studies on enamine catalysis provided insight into the rate determining step(s) of peptide catalyzed conjugate addition reactions between aldehydes and nitroolefins. They demonstrate that not enamine formation but both the reaction of the enamine with the electrophile and hydrolysis of the resulting imine are rate limiting. These results allowed for reducing the catalyst loading by a factor of 10 to as little as 0.1 mol %. This is the lowest catalyst loading that has been achieved so far in enamine catalysis with low molecular weight catalysts for a broad range of substrates.
Tripeptides as efficient asymmetric catalysts for 1,4-addition reactions of aldehydes to nitroolefins - A rational approach
Wiesner, Markus,Revell, Jefferson D.,Wennemers, Helma
, p. 1871 - 1874 (2008/12/22)
(Chemical Equation Presented) Bridging the gap: Conformational analysis of a peptidic catalyst for aldol reactions led to the development of H-D-Pro-Pro-Asp-NH2 as a highly efficient catalyst for conjugate addition reactions between aldehydes a
