1021397-45-4 Usage
Benzimidazole derivative
A class of compounds 2-(5-fluoro-2-methylphenyl)benzimidazole belongs to the class of benzimidazole derivatives, which are known for their diverse biological activities and potential applications in various fields.
Fluorine and methyl group attachment
Phenyl ring substitution In 2-(5-fluoro-2-methylphenyl)benzimidazole, a fluorine atom and a methyl group are attached to the phenyl ring, which may influence its chemical properties and potential applications.
Potential applications
Pharmaceutical and agrochemical fields 2-(5-fluoro-2-methylphenyl)benzimidazole has potential applications in pharmaceuticals and agrochemicals due to the diverse biological activities of benzimidazole derivatives.
Biological activities
Anticancer, antiviral, and antimicrobial properties Benzimidazole derivatives, including 2-(5-fluoro-2-methylphenyl)benzimidazole, have been studied for their various biological activities, such as anticancer, antiviral, and antimicrobial properties.
Handling precautions
Risks to human health and environment It is important to handle 2-(5-fluoro-2-methylphenyl)benzimidazole with care, as it may pose risks to human health and the environment if not properly managed and synthesized.
Check Digit Verification of cas no
The CAS Registry Mumber 1021397-45-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,1,3,9 and 7 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1021397-45:
(9*1)+(8*0)+(7*2)+(6*1)+(5*3)+(4*9)+(3*7)+(2*4)+(1*5)=114
114 % 10 = 4
So 1021397-45-4 is a valid CAS Registry Number.
1021397-45-4Relevant academic research and scientific papers
Synergic effect of copper-based metal-organic frameworks for highly efficient C-H activation of amidines
Xu, Fen,Kang, Wei-Fen,Wang, Xiao-Ning,Kou, Hao-Dong,Jin, Zhen,Liu, Chun-Sen
, p. 51658 - 51662 (2017/11/16)
A Cu-MOF-catalyzed C-H functionalization of substituted amidines was developed for the facile and efficient synthesis of benzimidazoles. More importantly, this transformation is compatible with various substrates derived from aryl nitriles without ortho substituents. Under reaction conditions devoid of O2 atmosphere or specific groups, 537-MOF has been revealed as a key parameter for expanding the reaction scope and increasing the yield up to 96%. Importantly, this strategy also provides numerous opportunities for further utilization of MOFs as catalysts for challenging organic reactions.
C-H functionalization/C-N bond formation: Copper-catalyzed synthesis of benzimidazoles from amidines
Brasche, Gordon,Buchwald, Stephen L.
, p. 1932 - 1934 (2008/12/22)
(Chemical Equation Presented) Copper closes the ring: Benzimidazoles are synthesized from amidines through a copper-catalyzed C-H functionalization/ C-N bond-forming process. The method tolerates a broad range of functional groups and provides the benzimidazoles in up to 89% yield. Best results are obtained by using 15 mol% Cu(OAc)2, 2-5 equivalents of HOAc as additive, and oxygen as the stoichiometric reoxidant (see scheme).
