1021427-49-5Relevant articles and documents
A convenient route to enantiopure 3-aryl-2,3-diaminopropanoic acids by diastereoselective Mannich reaction of camphor-based tricyclic iminolactone with imines
Zhang, Huan-Huan,Hu, Xiu-Qin,Wang, Xiao,Luo, Yong-Chun,Xu, Peng-Fei
, p. 3634 - 3637 (2008/09/20)
(Chemical Equation Presented) A novel and convenient route to the asymmetric synthesis of 2,3-diamino acids via Mannich reaction of iminolactones 1a and 1b with N-protected imines has been achieved in good yields (up to 95%) and high diastereoselectivity (dr: >99:1). Hydrolysis of the Mannich adducts under acidic conditions furnished the desired 3-aryl-2,3-diaminopropanoic acids in good yields (up to 85%) with excellent enantiomeric excesses (99% ee).