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1021435-06-2

ethyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-(ethanediylidene)-2,5-methanopyrido[2,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • ethyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-(ethanediylidene)-2,5-methanopyrido[2,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

    Cas No: 1021435-06-2

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  • Shanghai Yuanye Bio-Technology Co., Ltd.
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  • ethyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-(ethanediylidene)-2,5-methanopyrido[2,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate

    Cas No: 1021435-06-2

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  • XIUSHI BIOPHARMA(NANTONG) Co., Ltd
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  • 1021435-06-2 Structure

  • Basic information

    1. Product Name: ethyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-(ethanediylidene)-2,5-methanopyrido[2,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate
    2. Synonyms: ethyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-(ethanediylidene)-2,5-methanopyrido[2,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate
    3. CAS NO:1021435-06-2
    4. Molecular Formula:
    5. Molecular Weight: 595.736
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1021435-06-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: ethyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-(ethanediylidene)-2,5-methanopyrido[2,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: ethyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-(ethanediylidene)-2,5-methanopyrido[2,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate(1021435-06-2)
    11. EPA Substance Registry System: ethyl (2R,4S,7S)-7-cyclohexyl-23-methoxy-12,12-dimethyl-6,9-dioxo-3,4,6,7,8,9,12,13,14,15-decahydro-2H,11H-16,18-(ethanediylidene)-2,5-methanopyrido[2,3-k][1,10,3,6]dioxadiazacyclononadecine-4-carboxylate(1021435-06-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1021435-06-2(Hazardous Substances Data)

1021435-06-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1021435-06-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,1,4,3 and 5 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1021435-06:
(9*1)+(8*0)+(7*2)+(6*1)+(5*4)+(4*3)+(3*5)+(2*0)+(1*6)=82
82 % 10 = 2
So 1021435-06-2 is a valid CAS Registry Number.

1021435-06-2Relevant articles and documents

Discovery of MK-1220: A macrocyclic inhibitor of hepatitis C virus NS3/4A Protease with Improved Preclinical Plasma Exposure

Rudd, Michael T.,McCauley, John A.,Butcher, John W.,Romano, Joseph J.,McIntyre, Charles J.,Nguyen, Kevin T.,Gilbert, Kevin F.,Bush, Kimberly J.,Holloway, M. Katharine,Swestock, John,Wan, Bang-Lin,Carroll, Steven S.,Dimuzio, Jillian M.,Graham, Donald J.,Ludmerer, Steven W.,Stahlhut, Mark W.,Fandozzi, Christine M.,Trainor, Nicole,Olsen, David B.,Vacca, Joseph P.,Liverton, Nigel J.

scheme or table, p. 207 - 212 (2011/04/26)

The discovery of MK-1220 is reported along with the development of a series of HCV NS3/4A protease inhibitors containing a P2 to P4 macrocyclic constraint with improved preclinical pharmacokinetics. Optimization of the P2 heterocycle substitution pattern as well as the P3 amino acid led to compounds with greatly improved plasma exposure following oral dosing in both rats and dogs while maintaining excellent enzyme potency and cellular activity. These studies led to the identification of MK-1220.

HCV NS3 PROTEASE INHIBITORS

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Page/Page column 38; 39, (2008/12/05)

The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

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