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1021437-85-3

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1021437-85-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1021437-85-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,1,4,3 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1021437-85:
(9*1)+(8*0)+(7*2)+(6*1)+(5*4)+(4*3)+(3*7)+(2*8)+(1*5)=103
103 % 10 = 3
So 1021437-85-3 is a valid CAS Registry Number.

1021437-85-3Downstream Products

1021437-85-3Relevant articles and documents

Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease

Rudd, Michael T.,McCauley, John A.,Romano, Joseph J.,Butcher, John W.,Bush, Kimberly,McIntyre, Charles J.,Nguyen, Kevin T.,Gilbert, Kevin F.,Lyle, Terry A.,Holloway, M. Katharine,Wan, Bang-Lin,Vacca, Joseph P.,Summa, Vincenzo,Harper, Steven,Rowley, Michael,Carroll, Steven S.,Burlein, Christine,Dimuzio, Jillian M.,Gates, Adam,Graham, Donald J.,Huang, Qian,Ludmerer, Steven W.,McClain, Stephanie,McHale, Carolyn,Stahlhut, Mark,Fandozzi, Christine,Taylor, Anne,Trainor, Nicole,Olsen, David B.,Liverton, Nigel J.

, p. 7201 - 7206 (2013/01/15)

A series of macrocyclic compounds containing 2-substituted-quinoline moieties have been discovered and shown to exhibit excellent HCV NS3/4a genotype 3a and genotype 1b R155K mutant activity while maintaining the high rat liver exposure. Cyclization of the 2-substituted quinoline substituent led to a series of tricyclic P2 compounds which also display superb gt3a potency.

HCV NS3 PROTEASE INHIBITORS

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Page/Page column 36; 40, (2008/12/05)

The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections. (I)

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