1021452-36-7

Basic information

• Product Name: 2-(N-allyl-N-((S)-1-phenylethyl)amino)-N-tert-butoxy-N-methylacetamide
• Synonyms: 2-(N-allyl-N-((S)-1-phenylethyl)amino)-N-tert-butoxy-N-methylacetamide
• CAS NO: 1021452-36-7
• Molecular Weight: 304.433
• Mol File: 1021452-36-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(N-allyl-N-((S)-1-phenylethyl)amino)-N-tert-butoxy-N-methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N-allyl-N-((S)-1-phenylethyl)amino)-N-tert-butoxy-N-methylacetamide(1021452-36-7)
• EPA Substance Registry System: 2-(N-allyl-N-((S)-1-phenylethyl)amino)-N-tert-butoxy-N-methylacetamide(1021452-36-7)

Safety Data

• Hazardous Substances Data: 1021452-36-7(Hazardous Substances Data)

Upstream product

• 1021452-25-4 N-tert-butoxy-2-bromo-N-methylacetamide 
• 115914-08-4 (S)-N-(1-phenylethyl)prop-2-en-1-amine 

Downstream Products

• 1021452-38-9 (S)-2-(N-allyl-N-((S)-1-phenylethyl)amino)-N-methyl-2-phenylacetamide 
• 1105707-44-5 C₁₈H₂₈N₂O₂ 
• 1190882-06-4 (2S)-2-(N-allyl-N-((S)-1-phenylethyl)amino)-2-(4-fluorophenyl)-N-methylacetamide 
• 1190882-05-3 (2S)-2-(N-allyl-N-((S)-1-phenylethyl)amino)-2-(4-methoxyphenyl)-N-methylacetamide 
• 1190881-99-2 2-(N-allyl-N-((S)-1-phenylethyl)amino)-2-tert-butoxy-N-methylacetamide 
• 1190882-09-7 (2S)-2-(N-allyl-N-((S)-1-phenylethyl)amino)-2-(2-chlorophenyl)-N-methylacetamide 

Relevant articles and documents

Synthesis of aryl glycines by the α arylation of weinreb amides

(Chemical Equation Presented) A rare example of the umpolung of an enolate forms the basis of the title reaction. In this procedure, a Grignard reagent is added to the iminium ion formed from the Weinreb amide upon treatment with a base (see scheme). When a chiral amide was used as the starting material, the nucleophilic addition proceeded with high diastereoselectivity. LDA = lithium diisopropylamide.