1021460-67-2Relevant academic research and scientific papers
An acid-catalyzed ring-switch reaction of lactams to lactones: concise synthesis of 2,4-dialkyl-3-hydroxybutanolides
Yamauchi, Chiaki,Kuriyama, Masami,Shimazawa, Rumiko,Morimoto, Tsumoru,Kakiuchi, Kiyomi,Shirai, Ryuichi
, p. 3133 - 3140 (2008/09/20)
A novel approach for the synthesis of 2,4-dialkyl-3-hydroxybutanolides, having three successive stereogenic centers, by an acid-catalyzed ring-switch reaction of 2-(2-hydroxyalkyl)lactams is described. This transformation was applied to the synthesis of the key intermediates of teromerase inhibitor UCS1025A.
