1021601-84-2Relevant academic research and scientific papers
Syntheses with a chiral building block from the citric acid cycle: (2R,3S)-isocitric acid by fermentation of sunflower oil
Heretsch, Philipp,Thomas, Franziska,Aurich, Andreas,Krautscheid, Harald,Sicker, Dieter,Giannis, Athanassios
, p. 1958 - 1960 (2008/12/22)
(Chemical Equation Presented) No longer just analytical: Previously, (2R,3S)-isocitric acid (1), a component of the citric acid cycle, had not been available on a preparative scale. A new route to this acid on a kilogram scale combines a biotechnological formation through fermentation from sunflower oil with a chemical separation process. In a variety of transformations into further chiral derivatives, 1 is established as a valuable new member of the chiral pool (see scheme).
