1021698-63-4Relevant academic research and scientific papers
A microwave-assisted solvent- and catalyst-free synthesis of aminomethylene bisphosphonates
Kaboudin, Babak,Alipour, Soheil
, p. 4243 - 4245 (2009)
A convenient preparative approach for the synthesis of aminomethylene bisphosphonates is developed which involves treatment of amines with triethyl orthoformate and diethyl phosphite under microwave irradiation.
Bisphosphonate inhibitors of squalene synthase protect cells against cholesterol-dependent cytolysins
Pospiech, Mateusz,Owens, Sian E.,Miller, David J.,Austin-Muttitt, Karl,Mullins, Jonathan G. L.,Cronin, James G.,Allemann, Rudolf K.,Sheldon, I. Martin
, (2021/06/08)
Certain species of pathogenic bacteria damage tissues by secreting cholesterol-dependent cytolysins, which form pores in the plasma membranes of animal cells. However, reducing cholesterol protects cells against these cytolysins. As the first committed st
A facile synthesis of aminomethylene bisphosphonates through rhodium carbenoid mediated N-H insertion reaction. Application to the preparation of powerful uranyl ligands
Lecerclé, Delphine,Gabillet, Sandra,Gomis, Jean-Marie,Taran, Frédéric
, p. 2083 - 2087 (2008/09/17)
A straightforward procedure ensuring the anchoring of bisphosphonate moiety onto aromatic amines is described. The procedure yields aminoaryl 1,1-bisphosphonates known to display multiple biological activities. The described methodology has also been applied to the synthesis of ligands whose uranyl-binding properties have been studied.
