102170-53-6

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-3-chloro-6-methoxyaniline is used as a versatile reactant for the synthesis of thiazole and thiophene derivatives. These derivatives act as store-operated calcium channels modulators, which are useful in the treatment of SOC channel-mediated diseases. The compound's unique structure allows for the development of new drugs targeting specific calcium channels, potentially leading to more effective treatments for various conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-Bromo-3-chloro-6-methoxyaniline serves as a key intermediate for the production of various organic compounds. Its reactivity and functional groups make it a valuable component in the creation of new molecules with specific properties and applications, such as dyes, pigments, and other specialty chemicals.

Upstream product

• 89-61-2 2,5-dichloronitrobenzene 
• 95-03-4 5-chloro-2-methoxyaniline 
• 89-21-4 4-chloro-2-nitroanisole 

Downstream Products

• 1345117-76-1 N-[5-(5-chlorobenzoxazol-6-yl)(2-pyridyl)](2-chlorophenyl)carboxamide 
• 1346665-54-0 N-[4-(5-chloro-2-methylbenzoxazol-6-yl)phenyl](2-fluorophenyl)carboxamide 
• 1346665-53-9 4-(5-chloro-2-methylbenzoxazol-6-yl)phenylamine 
• 1346667-63-7 N-[4-(5-chloro-2-methylbenzoxazol-6-yl)phenyl](3-fluoro(4-pyridyl))carboxamide 
• 1613730-69-0 4-amino-2-chloro-3-iodo-5-methoxybenzonitrile 
• 1613730-70-3 4-amino-2-chloro-5-methoxy-3-((trimethylsilyl)ethynyl)benzonitrile 
• 5579-85-1 5,7-dibromo-6-hydroxy-2H-1,3-benzoxathiol-2-one 
• 1613730-68-9 4-amino-2-chloro-5-methoxybenzonitrile 
• 1366109-75-2 C₁₉H₁₂ClFN₂O₂Se 
• 1361379-08-9 [5-(5-chloro-2-methylbenzoxazol-6-yl)(2-thienyl)]-N-(2,6-difluorophenyl)carboxamide 
• 1361379-07-8 [5-(5-chloro-2-methylbenzoxazol-6-yl)(2-thienyl)]-N-(2-fluorophenyl)carboxamide 
• 1361379-06-7 [5-(5-chloro-2-methylbenzoxazol-6-yl)(2-thienyl)]-N-(2-chlorophenyl)carboxamide 
• 1345117-89-6 N-[5-(5-chloro-2-methylbenzoxazol-6-yl)(2-pyridyl)](2-chlorophenyl)carboxamide 
• 40372-61-0 2-amino-5-bromo-4-chlorophenol 

Relevant academic research and scientific papers

3-(6-CHLORO-3-OXO-3,4-DIHYDRO-(2H)-1,4-BENZOXAZIN-4-YL) PROPANOIC ACID DERIVATIVES AND THEIR USE AS KMO INHIBITORS

Compounds of formula (I) wherein: R1 is heteroaryl optionally substituted by methyl, ethyl, halo or =O; and R2 is H, methyl or ethyl. and salts thereof are KMO inhibitors and may be useful in the treatment of various disorders, for example acute pancreatitis, chronic kidney disease, other conditions associated with systemic inflammatory response syndrome (SIRS), Huntington's disease, Alzheimer's disease, spinocerebellar ataxias, Parkinson's disease, AIDS-dementia complex, HIV infection, amylotrophic lateral sclerosis (ALS), depression, schizophrenia, sepsis, cardiovascular shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe burns, pneumonia, extensive surgical procedures, ischemic bowel disease, severe acute hepatic disease, severe acute hepatic encephalopathy or acute renal failure.

3-(5-CHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC ACID DERIVATIVES AS KMO INHIBITORS

A compound of formula (I) or a salt thereof are provided wherein R1, X and R3 are defined in the specification, useful in the treatment of disorders mediated by KMO such as acute pancreatitis, chronic kidney disease, other conditions associated with systemic inflammatory response syndrome (SIRS), Huntington's disease, Alzheimer's disease, spinocerebellar ataxias, Parkinson's disease, AIDS-dementia complex, amylotrophic lateral sclerosis (ALS), depression, schizophrenia, sepsis, cardiovascular shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe burns, pneumonia, extensive surgical procedures, ischemic bowel, severe acute hepatic disease, severe acute hepatic encephalopathy or acute renal failure.