102178-06-3Relevant academic research and scientific papers
COMPOSITION FOR DIAGNOSIS OF AMYLOID-RELATED DISEASE
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, (2010/12/29)
There is provided a composition comprising a compound represented by general formula (I), wherein Rl represents a 5-iodothiophen-2-yl group or the like, and R2 represents a 4-dimethylaminophenyl group or the like. This composition is useful for diagnosis of an amyloid-related disease such as Alzheimer's disease because the compound has high binding specificity to amyloid β protein, high permeability through the blood-brain barrier, and a property of being rapidly eliminated from sites other than senile plaques in the brain.
COMPOSITION FOR DIAGNOSING AMYLOID-RELATED DISEASE
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Page/Page column 36; 56, (2009/04/23)
There is provided a composition comprising a compound represented by general formula (I), wherein R1 represents a 5-iodothiophen-2-yl group or the like, and R2 represents a 4-dimethylaminophenyl group or the like. This composition is useful for diagnosis of an amyloid-related disease such as Alzheimer's disease because the compound has high binding specificity to amyloid β protein, high permeability through the blood-brain barrier, and a property of being rapidly eliminated from sites other than senile plaques in the brain.
Fluoro-pegylated chalcones as positron emission tomography probes for in vivo imaging of β-amyloid plaques in Alzheimer's disease
Ono, Masahiro,Watanabe, Rumi,Kawashima, Hidekazu,Yan, Cheng,Kimura, Hiroyuki,Watanabe, Hiroyuki,Haratake, Mamoru,Saji, Hideo,Nakayama, Morio
experimental part, p. 6394 - 6401 (2010/03/31)
This paper describes the synthesis and biological evaluation of fluoro-pegylated (FPEG) chalcones for the imaging of β-amyloid (Aβ) plaques in patients with Alzheimer's disease (AD). FPEG chalcone derivatives were prepared by the aldol condensation reacti
