1021879-32-2

Basic information

• Product Name: C₃₉H₄₅N₅O₇
• CAS NO: 1021879-32-2
• Molecular Weight: 695.816
• Mol File: 1021879-32-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₉H₄₅N₅O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₉H₄₅N₅O₇(1021879-32-2)
• EPA Substance Registry System: C₃₉H₄₅N₅O₇(1021879-32-2)

Safety Data

• Hazardous Substances Data: 1021879-32-2(Hazardous Substances Data)

Upstream product

• 2017-68-7 2-(naphthalen-2-yl)ethanamine 
• 120267-95-0 Boc-Arg(Z)2-OH 

Relevant articles and documents

Identification of arginine analogues as antagonists and agonists for the melanocortin-4 receptor

In the present study, conducted to explore potent and small molecular melanocortin-4 (MC4) receptor ligands, we found that tripeptide 3a, containing a D-Phe-Arg-2-Nal (Nal; naphthylalanine) sequence, exhibited a moderate affinity for the MC4 receptor. Structural optimization led to the identification of a compound with a high affinity for the MC4 receptor, namely, tripeptide 3e, which showed a 70-fold higher affinity for the MC4 receptor than the lead compound 3a. Moreover, in an effort to further reduce the peptidic characters of tripeptide 3e, we found that dipeptide 3g exhibited a relatively high affinity for the MC4 receptor. Furthermore, in these analogues, the substituted position (1′ vs. 2′) of the naphthyl ring of Nal residue at position 7 was found to be important for the differentiation of agonist and antagonist activity. The synthesis and structure-activity relationships of the arginine analogues as MC4 receptor ligands were described in this paper.