1021939-48-9Relevant academic research and scientific papers
Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity
Hadden, Mark,Goodman, Allan,Guo, Cheng,Guzzo, Peter R.,Henderson, Alan J.,Pattamana, Kevin,Ruenz, Megan,Sargent, Bruce J.,Swenson, Brian,Yet, Larry,Liu, Jian,He, Shuwen,Sebhat, Iyassu K.,Lin, Linus S.,Tamvakopoulos, Constantin,Peng, Qianping,Kan, Yanqing,Palyha, Oksana,Kelly, Theresa M.,Guan, Xiao-Ming,Metzger, Joseph M.,Reitman, Marc L.,Nargund, Ravi P.
scheme or table, p. 2912 - 2915 (2010/07/02)
SAR around non-peptidic potent bombesin receptor subtype-3 (BRS-3) agonist lead 2 is presented. Attempts to replace the carboxylic acid with heterocyclic isosteres to improve oral bioavailability and brain penetration are described.
SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS
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Page/Page column 113, (2008/12/05)
Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.
