1022094-45-6

Basic information

• Product Name: 1-(β,β-difluorovinyl)4-phenylbenzene
• Synonyms: 1-(β,β-difluorovinyl)4-phenylbenzene
• CAS NO: 1022094-45-6
• Molecular Weight: 216.23
• Mol File: 1022094-45-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(β,β-difluorovinyl)4-phenylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(β,β-difluorovinyl)4-phenylbenzene(1022094-45-6)
• EPA Substance Registry System: 1-(β,β-difluorovinyl)4-phenylbenzene(1022094-45-6)

Safety Data

• Hazardous Substances Data: 1022094-45-6(Hazardous Substances Data)

Upstream product

• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 3218-36-8 4-Phenylbenzaldehyde 
• 438495-27-3 1-([1,1’-biphenyl]-4-yl)-2,2,2-trifluoroethanol 
• 98-80-6 phenylboronic acid 

Downstream Products

• 438495-27-3 1-([1,1’-biphenyl]-4-yl)-2,2,2-trifluoroethanol 

Relevant articles and documents

Visible-light-promotedE-selective synthesis of α-fluoro-β-arylalkenyl sulfidesviathe deoxygenation/isomerization process

Regioselective synthesis of α-fluoro-β-arylalkenyl sulfides has been established withgem-difluoroalkenes and sodium sulfinates in a transition-metal-free manner. A series of control experiments were executed to demonstrate thiol radicals and anions as the proposed intermediates. Notably, regioselectiveZ→Eisomerization was achieved under green light irradiation in the absence of a photoinitiator.

Palladium-Catalyzed Direct Approach to α-Trifluoromethyl Alcohols by Selective Hydroxylfluorination of gem-Difluoroalkenes

A novel palladium-catalyzed selective hydroxylfluorination of gem-difluoroalkenes has been developed. By employing easily obtainable gem-difluoroalkenes and NFSI as the fluorine source, the scope, advantages, and limitations of this reaction were investigated. The reaction presents an efficient synthesis to afford a series of α-trifluoromethyl alcohols in good to excellent yields. Furthermore, this reaction probably proceeds via oxidation of Pd0 to PdII fluoride complex by NFSI, followed by fluoropalladation of gem-difluoroalkenes to generate an α-trifluoromethylbenzyl–Pd intermediate. And this strategy offers more possibilities for the construction of other bonds, such as C–C, C–N and C–S.