102210-02-6

Basic information

• Product Name: 2-AMINO-3,3,3-TRIFLUORO-2-METHYLPROPANOIC ACID
• Synonyms: 2-AMINO-3,3,3-TRIFLUORO-2-METHYLPROPANOIC ACID;L-Alanine, 3,3,3-trifluoro-2-methyl- (9CI);2-Amino-3,3,3-trifluoro-2-methyl-propanoic acid Hydrochloride
• CAS NO: 102210-02-6
• Molecular Formula: C₄H₆F₃NO₂
• Molecular Weight: 157.09
• Product Categories: GLYCINESCAFFOLD
• Mol File: 102210-02-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 219.7±40.0 °C(Predicted)
• Appearance: /
• Density: 1.437±0.06 g/cm3(Predicted)
• PKA: 0.75±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-3,3,3-TRIFLUORO-2-METHYLPROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3,3,3-TRIFLUORO-2-METHYLPROPANOIC ACID(102210-02-6)
• EPA Substance Registry System: 2-AMINO-3,3,3-TRIFLUORO-2-METHYLPROPANOIC ACID(102210-02-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 102210-02-6(Hazardous Substances Data)

Usage

General Description

2-Amino-3,3,3-trifluoro-2-methylpropanoic acid is a chemical compound with the molecular formula C5H7F3NO2. It is a derivative of the amino acid valine and contains a trifluoromethyl group as well as an amino group. 2-AMINO-3,3,3-TRIFLUORO-2-METHYLPROPANOIC ACID has potential applications in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceuticals. It is also used in organic synthesis and as a reagent in chemical reactions. Additionally, it may have potential uses in the development of new materials and compounds with specific properties. However, it is important to handle this compound with caution, as it may pose health risks and can be harmful if not used properly.

Upstream product

• 676-58-4 methylmagnesium chloride 
• 216855-39-9 (S)-N-(p-tolylsulfinylimino)triphenylphosphorane 
• 911411-54-6 (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionitrile 
• 122008-12-2 3,3,3-trifluoro-2-amino-2-methylpropionamide 
• 102146-04-3 N-trifluoroacetyl-2-trifluoromethylalanine 

Downstream Products

• 1202059-63-9 (R)-α-Tfm-Ala-L-Ala-OBn 
• 1202059-68-4 (R)-α-Tfm-Ala-L-Leu-OBn 
• 1202059-66-2 (R)-α-Tfm-Ala-L-Phe-OtBu 
• 1422445-72-4 (R)-Cbz-Tfm-Ala-OH 

Relevant articles and documents

Chemo-enzymatic synthesis of chiral fluorine-containing building blocks

Two complementary strategies for the synthesis of optically active fluorine-containing building blocks have been probed. The first strategy involves either the enzymatic resolution of fluorinated α,α- disubstituted-α-amino acid amides, or the asymmetric h

Convenient synthesis of N-Terminal Tfm-Dipeptides from unprotected enantiopure α-Tfm-Proline and α-Tfm-alanine

A convenient procedure for the synthesis of highly lipophilic dipeptide building blocks from enantiopure α-trifluoromethyl α-amino acids is reported. Coupling reactions at the C termini of the trifluoromethyl a-amino acids were successfully performed with

The substrate specificity of the heat-stable stereospecific amidase from Klebsiella oxytoca

The substrate specificity of the heat-stable stereospecific amidase from Klebsiella oxytoca was investigated. In addition to the original substrate, 3,3,3-trifluoro-2-hydroxy-2-methylpropanamide, the amidase accepted 2-hydroxy-2-(trifluoromethyl)-butanamide and 3,3,3-trifluoro-2-amino-2- methylpropanamide as substrates. Compounds with larger side chains and compounds where the hydroxyl group was substituted with a methoxy group, or in which the CF3 group was substituted by CCl3, were not accepted. The biotransformation is a new synthetic route to (R)-(+)-3,3,3- trifluoro-2-amino-2-methylpropanoic acid, and its related (S)-(-)-amide, and to (R)-(+)-2-hydroxy-2-(trifluoromethyl)-butanoic acid and its related (S)-(-)-amide.