1022144-75-7Relevant academic research and scientific papers
Anthranilic acid replacements in a niacin receptor agonist
Schmidt, Darby,Smenton, Abigail,Raghavan, Subharekha,Shen, Hong,Ding, Fa-Xiang,Carballo-Jane, Ester,Luell, Silvi,Ciecko, Tanya,Holt, Tom G.,Wolff, Michael,Taggart, Andrew,Wilsie, Larissa,Krsmanovic, Mihajlo,Ren, Ning,Blom, Daniel,Cheng, Kang,McCann, Peggy E.,Waters, M.Gerard,Tata, James,Colletti, Steven
scheme or table, p. 3426 - 3430 (2010/08/07)
Niacin is an effective drug for raising HDL cholesterol. However, niacin must be taken in large doses and significant side effects are often observed, including facial flushing, loss of glucose tolerance, and liver toxicity. An anthranilic acid was identified as an agonist of the niacin receptor. In order to improve efficacy and provide structural diversity, replacements for the anthranilic acid were investigated and several compounds with improved properties were identified.
Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment
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Page/Page column 43, (2009/04/24)
The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
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Page/Page column 24; 34-35, (2008/12/05)
The present invention encompasses compounds of Formula (I) as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also
