1022149-33-2Relevant academic research and scientific papers
N-Methylation of adamantane-substituted oxalamide unit affects its conformational rigidity: A skew conformation of the oxalamide bridge
D?oli?, Zoran,Margeta, Renato,Vinkovi?, Marijana,?tefani?, Zoran,Koji?-Prodi?, Biserka,Mlinari?-Majerski, Kata,?ini?, Mladen
, p. 218 - 224 (2008/09/18)
The synthesis of adamantane functionalized retropeptides, N,N′-bis(2-adamantyl-2-carboxylic acid methyl ester)oxalamide (1) and N-methyl-N,N'-bis(2-adamantyl-2-carboxylic acid methyl ester)oxalamide (2), as well as the influence of the N-methylation on the conformational preferences of oxalamide group are described. In the solid state the oxalamide group of 1 is planar while in the retropeptide 2 adopts a skew-conformation.
