1022159-98-3Relevant academic research and scientific papers
De novo Design and synthesis of N-benzylanilines as new candidates for VEGFR tyrosine kinase inhibitors
Uno, Masaharu,Ban, Hyun Seung,Nabeyama, Wataru,Nakamura, Hiroyuki
scheme or table, p. 979 - 981 (2009/02/05)
N-Benzylanilines were designed and synthesized as vascular endothelial growth factor (VEGF)-2 inhibitors using de novo drug design systems based on the X-ray structure of VEGFR-2 kinase domain. Among compounds synthesized, compound 3 showed the most potent inhibitory activity toward VEGFR-2 (KDR) tyrosine kinase and its IC50 value was 0.57 μM.
