1022170-27-9

Upstream product

• 1022170-26-8 3-oxo-2-(1-phenyl-ethyl)-1-(prop-2-ynyl)-2,3-dihydro-1H-isoindole-1-carboxylic acid ethyl ester 

Downstream Products

• 1022170-28-0 2'-(1-phenyl-ethyl)-5-methylidene-4,5-dihydrospiro[furan-3(2H),1'-[1H]isoindole]-2,3'(2'H)-dione 
• 1022170-29-1 2'-(1-phenyl-ethyl)-5-methylidene-4,5-dihydrospiro[furan-3(2H),1'-[1H]isoindole]-2,3'(2'H)-dione 
• 1058239-64-7 2'-(1-phenylethyl)-5(E)-bromomethylidene-4,5-dihydrospiro[furan-1',3-isoindol-3'-one]-2-one 
• 1058239-62-5 2'-(1-phenylethyl)-5(E)-bromomethylidene-4,5-dihydrospiro[furan-1',3-isoindol-3'-one]-2-one 
• 1058239-65-8 2'-(1-phenylethyl)-5(E)-iodomethylidene-4,5-dihydrospiro[furan-1',3-isoindol-3'-one]-2-one 
• 1058239-63-6 2'-(1-phenylethyl)-5(E)-iodomethylidene-4,5-dihydrospiro[furan-1',3-isoindol-3'-one]-2-one 

Relevant academic research and scientific papers

Silver-catalyzed spirolactonization: first synthesis of spiroisoindole-γ-methylene-γ-butyrolactones

γ-Acetylenic carboxylic acids are cyclized to spirolactones under mild conditions, in the presence of Ag2CO3 catalyst. The corresponding spiro-5-alkylidene-γ-butyrolactones were isolated in high yields, and this process constitutes an easy and efficient route to analogous structures of natural products of biological interest.

Halolactonization of γ-acetylenic acids: systhesis of novel spiroisoindole halobutyrolactones

γ-Acetylenic carboxylic acids are cyclized to spirohalo butyrolactones, in the presence of NBS or NIS and K2CO3. The corresponding 5(E)-haloalkylidene-spirobutyrolactones were isolated in high yields, and this process constitutes an easy and efficient route to analogous structures of natural products of biological interest.