1022223-92-2Relevant academic research and scientific papers
Highly chemoselective reactions on hindered sulfamidates with oxygenated nucleophiles
Jimenez-Oses, Gonzalo,Avenoza, Alberto,Busto, Jesus H.,Peregrina, Jesus M.
, p. 443 - 449 (2008)
Although the chemoselectivity problems in substitution reactions, which arise from the use of oxygenated nucleophiles in a basic medium by generating anionic species are well-known, we report herein a highly chemoselective ring-opening reaction of hindered cyclic sulfamidates with O-nucleophiles. The reaction occurs with the inversion of configuration at the quaternary centre, allowing the stereoselective synthesis of an important class of β2,2-amino acids, namely O-substituted α-methylisoserines.
