1022900-38-4

Basic information

• Product Name: C₁₆H₁₈F₂N₂O₅
• Synonyms: C₁₆H₁₈F₂N₂O₅
• CAS NO: 1022900-38-4
• Molecular Weight: 356.326
• Mol File: 1022900-38-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₈F₂N₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₈F₂N₂O₅(1022900-38-4)
• EPA Substance Registry System: C₁₆H₁₈F₂N₂O₅(1022900-38-4)

Safety Data

• Hazardous Substances Data: 1022900-38-4(Hazardous Substances Data)

Upstream product

• 64248-63-1 3,5-difluorobenzonitrile 
• 4229-44-1 N-methylhydroxyamine hydrochloride 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 

Downstream Products

• 1022900-46-4 C₁₄H₁₂F₂N₂O₄ 

Relevant articles and documents

Tandem retro-Michael addition-Claisen rearrangement-intramolecular cyclization: One-pot synthesis of densely functionalized ethyl dihydropyrimidine-4-carboxylates from simple building blocks

Pyrolysis of suitably functionalized oxadiazoline diesters in refluxing xylenes provided ethyl 1,2-disubstituted 5-hydroxy-6-oxo-1,6-dihydropyrimidine- 4-carboxylates in moderate to good yields. Under thermal conditions, the oxadiazoline esters undergo a sequence of complex molecular reorganizations, namely retro-Michael addition, Claisen rearrangement, and cyclization, to produce the desired pyrimidinones. Georg Thieme Verlag Stuttgart.