1022945-75-0

Basic information

• Product Name: {8-[5-chloro-4-(2-fluoro-6-methylcarbamoylphenylamino)pyrimidin-2-ylamino]-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl}carbamic acid methyl ester
• Synonyms: {8-[5-chloro-4-(2-fluoro-6-methylcarbamoylphenylamino)pyrimidin-2-ylamino]-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl}carbamic acid methyl ester
• CAS NO: 1022945-75-0
• Molecular Weight: 555.996
• Mol File: 1022945-75-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {8-[5-chloro-4-(2-fluoro-6-methylcarbamoylphenylamino)pyrimidin-2-ylamino]-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl}carbamic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {8-[5-chloro-4-(2-fluoro-6-methylcarbamoylphenylamino)pyrimidin-2-ylamino]-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl}carbamic acid methyl ester(1022945-75-0)
• EPA Substance Registry System: {8-[5-chloro-4-(2-fluoro-6-methylcarbamoylphenylamino)pyrimidin-2-ylamino]-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl}carbamic acid methyl ester(1022945-75-0)

Safety Data

• Hazardous Substances Data: 1022945-75-0(Hazardous Substances Data)

Upstream product

• 1022972-70-8 3-amino-5,5-dimethyl-8-nitro-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 
• 1022972-67-3 3-azido-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one 
• 1022972-62-8 3-iodo-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one 
• 1022945-76-1 (5,5-dimethyl-8-nitro-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl)carbamic acid methyl ester 
• 1022972-64-0 5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 959246-74-3 2-(2,5-dichloro-pyrimidin-4-ylamino)-3-fluoro-N-methyl-benzamide 
• 1022945-77-2 (8-amino-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl)carbamic acid methyl ester 

Relevant articles and documents

Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group

The hepatocyte growth factor (HGF)-c-Met signaling axis is involved in the mediation of many biological activities, including angiogenesis, proliferation, cell survival, cell motility, and morphogenesis. Dysregulation of c-Met signaling (e.g., overexpress