1022956-07-5Relevant academic research and scientific papers
Methanesulfonamido-cyclohexylamine derivatives of 2,4-diaminopyrimidine as potent ALK inhibitors
Zificsak, Craig A.,Theroff, Jay P.,Aimone, Lisa D.,Angeles, Thelma S.,Albom, Mark S.,Cheng, Mangeng,Mesaros, Eugen F.,Ott, Gregory R.,Quail, Matthew R.,Underiner, Ted L.,Wan, Weihua,Dorsey, Bruce D.
, p. 3877 - 3880 (2011/08/06)
The incorporation of R,R-1,2-diaminocyclohexane at C4 in a series of 2,4-diaminopyrimidines led to a number of ALK inhibitors in which optimized activity was achieved by conversion of the 2-amino group into a methanesulfonamide. Tumor growth inhibition wa
FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS
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Page/Page column 318, (2008/12/05)
The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
