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2-amino-3-chloro-5-fluorobenzoic acid is a chemical compound with the molecular formula C7H5ClFNO2. It is a derivative of benzoic acid, featuring a chlorine and fluorine atom, as well as an amino group. 2-amino-3-chloro-5-fluorobenzoic acid is known for its unique structure and properties, making it a valuable tool in pharmaceutical and medical research.
Used in Pharmaceutical Industry:
2-amino-3-chloro-5-fluorobenzoic acid is used as a building block for the development of new drugs and medications. Its distinct chemical structure allows it to be a versatile component in the creation of various pharmaceutical compounds.
Used in Medical Research:
In the field of medical research, 2-amino-3-chloro-5-fluorobenzoic acid serves as a valuable tool for studying biochemical processes and interactions within the human body. Its presence can help researchers understand and potentially manipulate these processes for therapeutic benefits.

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  • 1022961-12-1 Structure
  • Basic information

    1. Product Name: 2-amino-3-chloro-5-fluorobenzoic acid
    2. Synonyms: 2-amino-3-chloro-5-fluorobenzoic acid
    3. CAS NO:1022961-12-1
    4. Molecular Formula: C7H5ClFNO2
    5. Molecular Weight: 189.5715032
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1022961-12-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 315.2±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.574±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
    8. Solubility: N/A
    9. PKA: 4.23±0.10(Predicted)
    10. CAS DataBase Reference: 2-amino-3-chloro-5-fluorobenzoic acid(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-amino-3-chloro-5-fluorobenzoic acid(1022961-12-1)
    12. EPA Substance Registry System: 2-amino-3-chloro-5-fluorobenzoic acid(1022961-12-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1022961-12-1(Hazardous Substances Data)

1022961-12-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1022961-12-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,2,9,6 and 1 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1022961-12:
(9*1)+(8*0)+(7*2)+(6*2)+(5*9)+(4*6)+(3*1)+(2*1)+(1*2)=111
111 % 10 = 1
So 1022961-12-1 is a valid CAS Registry Number.

1022961-12-1Upstream product

1022961-12-1Downstream Products

1022961-12-1Relevant articles and documents

Synthetic method of A2A adenosine receptor antagonist

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Paragraph 0034-0038, (2020/11/26)

The invention discloses a synthesis method of an A2A adenosine receptor antagonist, which comprises the following steps: by using 2-amino-5-fluorobenzoic acid as an initial raw material, carrying outan electrophilic substitution reaction with N-chlorosuccinimide to obtain an intermediate 1; carrying out a condensation acylation reaction on the intermediate 1 and urea to obtain an intermediate 2;carrying out cyclization on the intermediate 2 and phosphorus oxychloride to obtain an intermediate 3; subjecting the intermediate 3 and 2-furanboric acid to a coupling reaction to obtain an intermediate 4; protecting the intermediate 4 by a p-methoxybenzyl protecting group to obtain an intermediate 5; subjecting the intermediate 5 to a hydroxylation reaction to obtain an intermediate 6; subjecting the intermediate 6 and 4-(2-chloroethyl)-morpholine to a nucleophilic substitution reaction to obtain an intermediate 7; and removing the p-methoxybenzyl protecting group from the intermediate 7 toobtain the A2A adenosine receptor antagonist. The whole synthesis route is reasonable and mature, raw materials are easy to obtain, reaction conditions are mild, controllability is high, the method issuitable for industrial production, and the yield and purity of a target product are guaranteed.

FUSED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTCIAL COMPOSITION, AND USES THEREOF

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Paragraph 0232; 0233, (2016/09/26)

Disclosed are a fused heterocyclic compound, a preparation method therefor, a pharmaceutical composition, and uses thereof. The fused heterocyclic compound is shown in formula I, formula II, or formula III. The preparation method of the fused heterocyclic compound and/or the pharmaceutically acceptable salt thereof in the present invention comprises three synthesizing routes. The present invention also provides a pharmaceutical composition of the fused heterocyclic compound, the pharmaceutical composition containing one or more of the fused heterocyclic compound shown in formula I, formula II, or formula III, the pharmaceutically acceptable salt thereof, hydrates, solvent compounds, polymorphs and prodrugs thereof, and a pharmaceutically acceptable carrier. The present invention also relates to an application of the fused heterocyclic compound and/or the pharmaceutical composition in preparing kinase inhibitors and in preparing drugs for preventing and treating diseases related to kinase. The fused heterocyclic compound of the present invention has selective inhibition function on PI3Kδ, and can be used for preparing drugs for preventing and treating cell proliferation diseases such as cancers, infections, inflammations, or autoimmune diseases.

Synthesis of insecticidal fluorinated anthranilic diamides

Clark, David A.,Lahm, George P.,Smith, Ben K.,Barry, James D.,Clagg, Don G.

, p. 3163 - 3170 (2008/09/20)

A series of highly active fluorinated anthranilic diamide insecticides have been prepared and their biological activity assessed on two aphid species in the search for systemically active compounds that control Hemiptera. In addition, we have demonstrated a new synthesis of N-aryl 3-fluoropyrazoles.

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