1022971-87-4

Upstream product

• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 1245830-90-3 (1R,2R)-N-(2,5-dichloro-pyrimidin-4-yl)cyclohexane-1,2-diamine 
• 108-24-7 acetic anhydride 

Downstream Products

• 1245828-73-2 N-{(1R,2R)-2-[5-chloro-2-(2-methoxy-phenylamino)pyrimidin-4-ylamino]cyclohexyl}acetamide 
• 1022973-31-4 N-{(1R,2R)-2-[5-chloro-2-(3-ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino)pyrimidin-4-ylamino]cyclohexyl}acetamide 

Relevant academic research and scientific papers

Methanesulfonamido-cyclohexylamine derivatives of 2,4-diaminopyrimidine as potent ALK inhibitors

The incorporation of R,R-1,2-diaminocyclohexane at C4 in a series of 2,4-diaminopyrimidines led to a number of ALK inhibitors in which optimized activity was achieved by conversion of the 2-amino group into a methanesulfonamide. Tumor growth inhibition wa

SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER

The present invention encompasses compounds of general formula (1) wherein B, R1 to R5, Rx, m and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use in such treatment.