1022980-42-2Relevant academic research and scientific papers
Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer
Gandhi, Viraj B.,Luo, Yan,Liu, Xuesong,Shi, Yan,Klinghofer, Vered,Johnson, Eric F.,Park, Chang,Giranda, Vincent L.,Penning, Thomas D.,Zhu, Gui-Dong
scheme or table, p. 1023 - 1026 (2010/06/14)
Through conformational restriction of a benzamide by formation of a seven-membered hydrogen-bond with an oxindole carbonyl group, a series of PARP inhibitors was designed for appropriate orientation for binding to the PARP surface. This series of compound
POLY(ADP-RIBOSE)POLYMERASE INHIBITORS
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Page/Page column 11, (2008/12/04)
Compounds which inhibit the activity of poly(ADP-ribose)polymerase, compositions containing the compounds and methods of treating diseases using the compounds is disclosed.
