1022981-72-1

Upstream product

• 27489-62-9 trans-4-hydroxycyclohexylamine 
• 13526-66-4 3-bromo-6-chloro-imidazo[1,2-b]pyridazine 
• 27489-62-9 trans-4-aminocyclohexan-1-ol 

Downstream Products

• 923597-85-7 4-[3-(2-chloro-pyridin-4-yl)-imidazo[1,2-b]pyridazin-6-ylamino]-cyclohexanol 
• 1022981-43-6 4-[3-(4-pyrazol-1-yl-phenyl)-imidazo[1,2-b]pyridazin-6-ylamino]-cyclohexanol 

Relevant academic research and scientific papers

MIXED LINEAGE KINASE INHIBITORS AND METHOD OF TREATMENTS

Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of

HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS

A compound of Formula Ia or Ib in free or salt or solvate form, where R1, R2, R3, R4, R5 R20, R24, R25, X, Y and Z have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. These compounds are also useful for treating diseases mediated by the Pi3k receptor, the JAK-2 receptor and the TRK receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.