1022984-23-1

Basic information

• Product Name: 5-chloro-2-(4-dimethylaminophenyl)-2,3-dihydroisoindol-1-one
• CAS NO: 1022984-23-1
• Molecular Weight: 286.761
• Mol File: 1022984-23-1.mol

Chemical Properties

• CAS DataBase Reference: 5-chloro-2-(4-dimethylaminophenyl)-2,3-dihydroisoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-(4-dimethylaminophenyl)-2,3-dihydroisoindol-1-one(1022984-23-1)
• EPA Substance Registry System: 5-chloro-2-(4-dimethylaminophenyl)-2,3-dihydroisoindol-1-one(1022984-23-1)

Safety Data

• Hazardous Substances Data: 1022984-23-1(Hazardous Substances Data)

Upstream product

• 145908-29-8 methyl 2-(bromomethyl)-4-chlorobenzoate 
• 99-98-9 4-amino-N,N-dimethylaniline 

Relevant articles and documents

ISOINDOLONES WITH HIGH BINDING AFFINITY TO BETA-AMYLOID AGGREGATES AND FIBRILS, AND ITS USE AND PREPARATION METHOD

The present invention relates to isoindolone compounds having high binding affinity to beta-amyloid fibrils, thereby being useful for an early diagnosis of degenerative cerebral diseases including dementia, and prevention and treatment of such diseases, i

Isoindol-1,3-dione and isoindol-1-one derivatives with high binding affinity to β-amyloid fibrils

Based on the structural features of Indoprofen and PIB, a series of isoindol-1,3-diones 1a-k and isoindol-1-ones 2a-l were designed and synthesized. These 23 compounds were evaluated by competitive binding assay against aggregated Aβ42 fibrils using [125I]TZDM. All the isoindolone derivatives showed very good binding affinities with Ki values in the subnanomolar range (0.42-0.94 nM). Among them, isoindol-1,3-diones 1i and 1k and isoindol-1-ones 2c and 2i exhibited excellent binding affinities (Ki = 0.42-0.44 and 0.46-0.49 nM) than those of Indoprofen (Ki = 0.52 nM) and PIB (Ki = 0.70 nM). These results suggest that isoindolones could be served as a scaffold for potential AD diagnostic probes to monitor Aβ fibrils.