1022985-47-2Relevant academic research and scientific papers
Enantioselective organocatalytic Michael addition of aldehydes to nitroethylene: Efficient access to γ2-amino acids
Chi, Yonggui,Guo, Li,Kopf, Nathan A.,Gellman, Samuel H.
, p. 5608 - 5609 (2008/12/22)
Enantioselective organocatalytic Michael addition of aldehydes to nitroethylene catalyzed by (S)-diphenylprolinol silyl ether provides β-substituted-δ-nitroalcohols in nearly optically pure form (96-99% ee). The Michael adducts bear a single substituent adjacent to the carbonyl and can be efficiently converted to protected γ2-amino acids, which are essential for the systematic conformational studies of γ-peptide foldamers. Copyright
